Non-melanoma Skin Cancer
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Jun 08 – Jun 15, 2026
Simulated daylight versus conventional PDT for mild to moderate actinic keratoses: A randomized controlled trial.
J EUR ACAD DERMATOL · Q1 JOURNAL - RANK #6/96
This single-centre, randomized controlled trial evaluated the non-inferiority of simulated daylight photodynamic therapy (SDL-PDT) versus conventional photodynamic therapy (C-PDT) in treating mild to moderate actinic keratoses (AKs), randomizing anatomical sites in 69 adult participants (1458 AK lesions total) to receive each intervention. Methods included pain assessments (NRS 0-10), patient preference self-reports, and follow-up for early failure (3 months) and overall clearance rates (1 year). After one year, lesion clearance was 71.0% for SDL-PDT and 85.3% for C-PDT (p < 0.001), failing non-inferiority, but SDL-PDT was markedly less painful (mean NRS: 0.8 vs. 6.6, p < 0.001), with 98.3% of patients preferring SDL-PDT. Conclusions highlight SDL-PDT’s lower effectiveness but improved tolerability, supporting its consideration for patients valuing comfort.
10.1111/jdv.70556