Anal Cancer
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May 04 – May 11, 2026
Survival outcomes in POD1UM-303/InterAACT-2: a phase 3 study of retifanlimab plus carboplatin-paclitaxel in first-line advanced squamous anal cancer.
ANN ONCOL · Q1 JOURNAL - RANK #4/326TOP-TIER
This phase 3, randomized, double-blind trial (POD1UM-303/InterAACT-2) evaluated the efficacy of adding retifanlimab to carboplatin-paclitaxel as first-line treatment for 308 patients with advanced or metastatic squamous cell carcinoma of the anal canal. Results demonstrated a significant improvement in median overall survival (32.8 vs. 22.2 months; HR 0.75) and progression-free survival (HR 0.62) compared to chemotherapy alone. The combination therapy achieved a higher overall response rate of 56.5% versus 44.8% and maintained a consistent benefit across all analyzed subgroups without new safety concerns. These findings establish retifanlimab plus chemotherapy as a new reference standard of care for patients with inoperable, locally recurrent, or metastatic anal cancer.
10.1016/j.annonc.2026.04.016
Apr 06 – Apr 13, 2026
Nine-Valent Human Papillomavirus Vaccination and Related Cancers in Males.
JAMA ONCOL · Q1 JOURNAL - RANK #14/326TOP-TIER
This multicenter retrospective cohort study evaluated the effectiveness of the 9-valent HPV vaccine in preventing HPV-related cancers in males aged 9-26 years, finding vaccinated males had a 46% lower risk of developing composite HPV-related cancers (HR 0.54, 95% CI 0.37-0.81) compared to unvaccinated males over up to 10 years of follow-up. The study’s primary focus was on cancer prevention, specifically head and neck, esophageal, anal, and penile cancers, with significant risk reduction maintained across age subgroups (9-14 years: HR 0.58; 15-26 years: HR 0.50). These results directly address cancer prevention as a primary research focus by demonstrating vaccine effectiveness against multiple cancer types. The findings strongly support implementing sex-neutral HPV vaccination policies to reduce the future burden of HPV-associated cancers in males.
10.1001/jamaoncol.2026.0496